The force to which a muscle is exposed during the first repetition of an exercise is potentially high because the muscle is fresh and capable of producing its highest level of exertion and greatest speed at that moment. If you initiate the first repetition with a jerk or excess speed, you invite injury. To avoid potential problems, slowly press into the resistance (bar, pad or other) with enough effort to barely allow it to move, then continue (throughout the range of motion) producing a force slightly greater than the weight itself. The effort should produce a slow, controlled movement.
What does that mean? During the final repetition, when it feels like your limb will disconnect, the muscle cannot produce the potential force it could during the first repetition. It's tired. Even if you tried to jerk the weight through the final repetition (which you should not), you cannot produce enough force to create injury.
Therefore, despite the way it feels, the last repetition of a set is always safer than the first. Unfortunately, many trainees train by feel, quit before they should - somewhere short of muscle failure - and ruin the potential to stimulate tissue change. All because of fear of injury - a fear not supported by fact.
Work as hard as you can - the harder, the safer.
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